Current Situation of Adipose-Derived Stem Cells Treatments for Knee Ostheoarthritis and Hypothesis for a New Protocol Based on Cryoconservation and Multiple Injections of Mechanically Fragmented Adipose Tissue Extracts
نویسندگان
چکیده
Osteoarthritis (OA) is a widespread degenerative joint disease. The knee arthroplasty has represented for about 40 years the main treatment option, when pain and functional decrease became unbearable patient. represents challenging surgical operation, in which, based on current data available, 20% of patients are left totally or partially unsatisfied with clinical result. A recent therapeutic alternative mild-to-moderate grade OA (Kellgren-Lawrence II to III) order delay (or ultimately avoid) need prosthetic surgery, Adipose-Derived Stem Cells ADSCs). safety efficacy terms improvement, cartilage repair inflammation reduction were already reported through single intra-articular injection Micro-Fragmented Autologous Fat Tissue (M-FAT), which known be rich ADSCs. This period appears ranging from several months few years. Research shown that effect single-dose M-FAT treatment, despite being evident most cases, not statistically uniform among studies now available. also due different protocols, leave every research group ultimate choice preparation methods, rules exclusion criteria. It possible, because this, hypothesize new kind protocol harvesting operation. extract would then cryopreserved administered multiple times over several-years period. We hope, thanks subsequent injections purified extract, prolong boost treatment. tried elaborate, our experience field, this multi-injection going applied small number evaluated time, elaborate actual benefit like this.
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ژورنال
عنوان ژورنال: Medical research archives
سال: 2023
ISSN: ['2375-1916', '2375-1924']
DOI: https://doi.org/10.18103/mra.v11i6.3747